Female dwarf bunny change in behavior

Hello:

 I have a 5 yr old female dwarf rabbit who is spayed. I've had her since she was 2 mo old and she was easily litter trained both with pee and poo. She is adorable and has friendliest personality of any rabbit I've ever owned.  A few mo ago, however, she started pooping outside her litter boxes.  I keep her in a 5'x7' pen that  has an open cage inside it. She jumps in and out of the cage at will. She spends a good part of her day going back and forth between the cage and her pen. I keep one litter box is in the cage and one in the pen.
Almost a year ago, we moved to a new house.  I have a walk-out basement and my bunny has her pen in my living room.  Everything has been fine until about 4 mo ago.  I picked her up and was holding her like I always do and she suddenly urinated all over me.  I put her in her litter box which she jumped right out of.  Since that time, she has done the same thing about 2-3 more times.  Can you tell me what the problem might be?
I have been picking her up less and just sitting in her pen w/her and letting her come to me.  Then I give her a treat and pet her.
Tonight I noticed she peed outside her litter box inside the cage.  She has done this only occasionally since I adopted her. 
Can you please tell me why she may be displaying this sudden behavior of urinating on me?  Also, can you shed any light on how I might get her to start pooping in her box again?

Thank you!